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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complexA variation within <i>TRMT2Bi> (c.1356G>T; p.K452N) was identified to be associated with ALS in a familyA decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrialcomplex I activities, lower mitochondrial aerobic respiration, and a high level of ROS were observedFurther, <i>TRMT2Bi> variations overexpression cells also displayed decreased ND1.

Keywords： <i>TRMT2Bi>     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: In addition, cell imaging shows that this probe can be used for the mitochondrial targeted detection

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

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hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,Herein, we constructed an <i>in situi> hydrophobic environment-triggering reactive fluorescence probeThe fluorophore was 2-styrene-1<i>Hi>-benzo[<i>di>]imidazole, and malononitrile was introduced asThus, MBI-CN can be hydrolyzed to generate MBI-CHO in an <i>in situi> hydrophobic environment withmitochondrial DNA damage.

Keywords： hydrolysis reaction     mitochondrial DNA damage     <i>in situi> hydrophobic environment trigger     fluorescence    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract:

Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important>GP I complex.The interaction between the anti-β2GP I /β2GP I complex and plateletsOur results revealed that the anti-β2GP I /β2GP I complex was able toResults showed that the anti-β2GP I /β2GP I complex induced platelet

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: healthy subjects with high sensitivity (80.4%) and specificity (79.4%) even in the early stage (Stage I:Moreover, <i>in vitroi> studies indicated that circulating tRF-Gln-TTG-006 was released from tumor

Keywords： tsRNA     biomarker     hepatocarcinoma    

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Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 358-365 doi: 10.15302/J-FASE-2017158

Abstract: Substantial variation in gene organization and arrangement has been reported for sequenced mitochondrial

Keywords： gene rearrangement     mitochondrial genome     Psocoptera     Stenopsocidae     TDRL model    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of <i>Fusarium graminearumi> on Wheat Article

Xuli Wang, Xin Xie, Jin Liu, Guo-Liang Wang, Dewen Qiu

Engineering 2020, Volume 6, Issue 5,   Pages 546-552 doi: 10.1016/j.eng.2019.07.025

Abstract: In this study, we characterized the function of the nascent polypeptide-associated complex (NAC) in <

Keywords： Fusarium head blight     Nascent polypeptide-associated complex     Gene knockout     Pathogenicity     Subcellular    

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Unified construction of two <i>ni>-order circuit networks with diodes Research Article

Xiaoyan LIN, Zhizhong TAN

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 2,   Pages 289-298 doi: 10.1631/FITEE.2200360

Abstract: In this paper, two different -order topological circuit networks are connected by diodes to establish a unified network model, which is a previously unexplored problem. The network model includes not only five resistive elements but also diode devices, so the network contains many different network types. This problem can be solved through three main steps: First, the network is simplified into two different equivalent circuit models. Second, the model is established by applying Kirchhoff’s law. Finally, the two equations with similar structures are processed uniformly, and the general solutions of the s are obtained by using the transformation technique. As an example, several interesting specific results are deduced. Our study on the network model has significant value, as it can be applied to relevant interdisciplinary research.

Keywords： Complex networks     Equivalent transform     Nonlinear difference equation     Equivalent resistance    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: Direct DNA-sequencing analysis techniques were used to detect mitochondrial sequence variants between

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: interacts with the core subunits of the glucose-induced degradation-deficient (GID) ubiquitin ligase complex, an evolutionarily conserved ubiquitin ligase complex and is ubiquitinated by itself.The protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiationTET2 level increased in the brain of the <i>Wdr26i>+/− mice.Our results illustrated that the GID complex negatively regulates TET2 protein stability, further modulates

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: However, this disease is multifactorial, and its mechanism is poorly understood due to the complex pathogenesisthe aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrial

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: contribute to TG anabolism, and the decreased Lipin1 in nucleoplasm can reduce PGC1α, further leading to mitochondrialWe also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Footholds optimization for legged robots walking on complex terrain

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0742-y

Abstract: novel continuous footholds optimization method for legged robots to expand their walking ability on complexslipping or tripping on the edge of obstacles, and to improve its stability and safety when walking on compleximplemented the algorithm on a hexapod robot, and verified its feasibility in a walking experiment on a complex

Keywords： footholds optimization     legged robot     complex terrain adapting     hexapod robot     locomotion control    

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Special issue: Reliability management of complex system

Frontiers of Engineering Management 2021, Volume 8, Issue 4,   Pages 477-479 doi: 10.1007/s42524-021-0175-z

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Title Author Date Type Operation

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNA

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article

Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Journal Article

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of <i>Fusarium graminearumi> on Wheat

Xuli Wang, Xin Xie, Jin Liu, Guo-Liang Wang, Dewen Qiu

Journal Article

Unified construction of two <i>ni>-order circuit networks with diodes

Xiaoyan LIN, Zhizhong TAN

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Journal Article

Footholds optimization for legged robots walking on complex terrain

Journal Article

Special issue: Reliability management of complex system

Journal Article